Monday, 20 January 2014

Association of Myocardial Dysfunction with Vitamin D Deficiency in Patients with Type 2 Diabetes Mellitus

In patients with T2DM and no history of coronary artery disease, vit-D deficiency is independently associated with impaired global longitudinal strain. This suggests that vit-D deficiency may contribute to the development of myocardial dysfunction in these patients (Journal of Diabetes and Its Complications)

Old and New Basal Insulin Formulations: Understanding Pharmacodynamics is Still Relevant in Clinical Practice

Despite (in fact because of) the widespread use of insulin analogues it remains critical to analyse the pharmacodynamics (PD) of basal insulin formulations appropriately to interpret the results of clinical trials correctly. Importantly, these data may help physicians in tailoring insulin therapy to patients’ individual needs and, additionally, when clinical evidence is not available, to optimise insulin treatment (Diabetes, Obesity and Metabolism)

How many people inject insulin? UK estimates from 1991 to 2010

The crude prevalence rate of insulin use increased from 2.43 per 1,000 population in 1991 to 6.71 per 1,000 in 2010. The largest change was an increase in the prevalence of insulin users with a diagnosis of type 2 diabetes from 0.67 to 4.34 per 1000 population. The absolute number using insulin increased from 137,000 people in 1991 to 421,000 in 2010 (Diabetes, Obesity and Metabolism)

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