Tuesday, 18 March 2014

Sanofi launches its new generation blood glucose monitor

MyStar Extra® is the first device to support insulin therapy management with estimated HbA1c (Sanofi)

Association between low blood glucose increase during glucose tolerance tests in pregnancy and impaired fetal growth

In a high-risk population, a positive relation between glucose and fetal growth was found. Group Low demonstrated impaired growth. More attention should be paid to pregnant women with an insufficient increase in glucose after a glucose challenge. Future studies should challenge our findings in high- and low-risk populations (Acta Obstetricia et Gynecologica Scandinavica)

Use of Antidiabetic Drugs in the U.S., 2003–2012

The antidiabetic drug market is characterized by steady increases in volume, and newly approved drugs experienced substantial uptake, especially DPP-4 inhibitors. The use of rosiglitazone has been negligible since restrictions were put in place in 2011. Further study is needed to understand why one-third to one-half of other noninsulin antidiabetic drug use was not concomitant with metformin use despite guidelines recommending that metformin be continued when other agents are added to treatment (Diabetes Care)

Insulin Sensitivity and Albuminuria: The RISC Study

In healthy middle-aged adults, reduced insulin sensitivity, assessed by hyperinsulinemic–euglycemic clamp, is continuously associated with a greater risk of increasing albuminuria. This finding suggests that reduced insulin sensitivity is either simply related to or might causally contribute to the initial pathogenesis of albuminuria (Diabetes Care)

The Cytotoxic Role of Intermittent High Glucose on Apoptosis and Cell Viability in Pancreatic Beta Cells

This study suggested that IHG plays a more toxic effect including both apoptosis-inducing and antiproliferative effects on INS-1 cells. Excessive activation of cellular stress and regulation of cyclins might be potential mechanism of impairment in INS-1 cells induced by IHG (Journal of Diabetes Research)

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