Tuesday, 15 April 2014

SGLT2 inhibitors in the treatment of type 2 diabetes

This article summarizes the rationale for use of these agents and reviews available clinical data on their efficacy, safety, and risks/benefits (Diabetes Research and Clinical Practice)

Observational Study of Kidney Function and Albuminuria in Patients With Type 2 Diabetes Treated With Exenatide BID Versus Insulin Glargine

There were no significant differences in change in kidney function or albuminuria at 1 year in patients treated with exenatide BID compared with insulin glargine as administered in routine practice (Annals of Pharmacotherapy)

Screening for Peripheral Neuropathies in Children With Diabetes: A Systematic Review

Data show extremely low diagnostic utility for standard screening methods (tuning fork and 10-g monofilament) but acceptable utilities for biothesiometry and finer (1 g) monofilaments. Data on the diagnostic utility should be used to inform national and international guidelines on diabetes management (Pediatrics)

Gene expression changes in cancellous bone of type 2 diabetics: a biomolecular basis for diabetic bone disease

This study identifies considerable changes in the expression of transcription factors and extracellular matrix (ECM) components of bone in 2DM patients. Furthermore, the analysis of key differentiation factors of osteoblasts revealed significant alterations in gene expression of these factors, which may contribute to the dysregulation of energy metabolism in 2DM (Langenbeck's Archives of Surgery)

Two new book reviews on Glycosmedia

Cancer Virus: The story of Epstein-Barr Virus - Davidson’s Principles and Practice of Medicine

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