Thursday, 29 May 2014

Very-low-energy diet for type 2 diabetes: An underutilized therapy?

An intensive, outpatient, behavioral weight management program significantly improved HbA1c in patients with type 2 diabetes over 12 weeks. The use of such programs should be encouraged among obese patients with type 2 diabetes (Journal of Diabetes and Its Complications)

Exenatide once weekly versus insulin glargine for type 2 diabetes (DURATION-3): 3-year results of an open-label randomised trial

Efficacy of once-weekly exenatide is sustained for 3 years. GLP-1 receptor agonists could be a viable long-term injectable treatment option in patients with type 2 diabetes who have not yet started taking insulin (The Lancet Diabetes & Endocrinology)

Wednesday, 28 May 2014

Safety and efficacy of the DPP-4 inhibitor linagliptin in elderly patients with type 2 diabetes: a comprehensive analysis of data from 1331 individuals aged =65 years

Data from this large cohort demonstrate that linagliptin is a well-tolerated and efficacious therapy for elderly patients with T2DM (Diabetes, Obesity and Metabolism)

DPP-4 inhibitors can minimize the hypoglycemic burden and enhance safety in elderly people with diabetes

Although more information is needed to reach definitive conclusions, growing evidence suggests that DPP4-I may become a valuable component in the pharmacologic management of elderly persons with T2DM (Diabetes, Obesity and Metabolism)

Tuesday, 27 May 2014

Pancreas volume measurement in patients with Type 2 diabetes using magnetic resonance imaging-based planimetry

PV is reduced in Type 2 DM compared to normoglycemic individuals and can be measured using MRI without contrast injection (Pancreatology)

Differences in skeletal and non-skeletal factors in a diverse sample of men with and without type 2 diabetes mellitus

Men with T2DM have lower muscle mass and strength, but similar BMD, compared to their non-diabetic counterparts. These differences in non-skeletal factors might explain, at least in part, the higher incidence of falls and fractures observed in T2DM patients (Journal of Diabetes and Its Complications)

The Association between Serum Uric Acid and Residual ß-Cell Function in Type 2 Diabetes

Patients with higher sUA have greater insulin secretion ability than those with lower sUA at the early stage of disease, but their residual ß-cell function seems to decay more rapidly (Journal of Diabetes Research)

Friday, 23 May 2014

Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges?

Here we review current evidence and circumstances in which insulin can be used, consider individualized choices of alternatives and combination regimens, and offer some guidance on personalized targets and tactics for glycemic control in type 2 diabetes (Diabetes Care)

Type 2 diabetes: European Commission approves Jardiance® (empagliflozin) tablets for use in adults in Europe

European Commission approves third product from the Boehringer Ingelheim and Lilly Diabetes alliance

Plasma advanced glycation endproducts are associated with incident cardiovascular events in individuals with type 2 diabetes: a case-cohort study with a median follow-up of 10 years (EPIC-NL)

high plasma AGEs were associated with incident cardiovascular events in individuals with T2DM. These results underline the potential importance of AGEs in development of CVD (Diabetes)

Thursday, 22 May 2014

GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects with Type 2 Diabetes

Our data suggest the enhanced GLP-1 secretion observed long-term after SG is neither sufficient nor critical to maintain normal glucose tolerance in subjects with T2DM antedating the surgery (Diabetes)

Increase in physical activity is associated with lower HbA1c levels in children and adolescents with type 1 diabetes

Physical activity seems to influence HbA1c levels in children and adolescents with type 1 diabetes. In clinical practice these patients should be recommended daily physical activity as a part of their treatment (Diabetes Research and Clinical Practice)

The Association Between Depressive Symptoms and Systemic Inflammation in People With Type 2 Diabetes: Findings From the South London Diabetes Study

Increased inflammation may be involved in the pathogenesis of depressive symptoms in type 2 diabetes and contribute to the increased risk of complications and mortality in this group (Diabetes Care)

Wednesday, 21 May 2014

Statin paper in the BMJ

Access to the original submission and updated versions of this article, showing tracked changes, plus peer review feedback (BMJ)

Comparison of conventional pattern and novel navigated panretinal photocoagulation in proliferative diabetic retinopathy

Navigated laser treatment achieves more uniform laser burns with less pain during shorter treatment duration in comparison to conventional pattern laser (Investigative Ophthalmology & Visual Science)

Tuesday, 20 May 2014

Variations in erythrocyte antioxidant levels and lipid peroxidation status and in serum lipid profile parameters in relation to blood haemoglobin A1c values in individuals with type 2 diabetes mellitus

These results suggest that HbA1c values may be potentially useful not only to indicate long-term glycemic control to indicate onset of complications at a clinically detectable level and molecular level (Diabetes Research and Clinical Practice)

Monday, 19 May 2014

Insulin secretion measured by stimulated C-peptide in long-established Type 1 diabetes in the Diabetes Control and Complications Trial

These results show that a stimulated C-peptide response can be measured in some people with long-term Type 1 diabetes (Diabetic Medicine)

Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials

Behavioural interventions that deal with both diet and physical activity show small but significant benefits on weight loss maintenance (British Medical Journal)

Friday, 16 May 2014

Cardiac autonomic neuropathy predicts renal function decline in patients with type 2 diabetes: a cohort study

CAN was independently associated with CKD, albuminuria and eGFR in patients with type 2 diabetes. In addition, CAN was an independent predictor of the decline in eGFR over the follow-up period (Diabetologia)

Thursday, 15 May 2014

Type 2 diabetes: findings presented from retrospective analysis of pooled data examining linagliptin in African-American adults

African-Americans have an increased risk of developing type 2 diabetes and are less likely to achieve glycemic targets due to genetic and environmental factors, yet they are underrepresented in clinical trials ... The findings from this retrospective pooled data analysis help support the efficacy and safety profile of linagliptin as a treatment option for African-American adults with type 2 diabetes (Lilly)

Wednesday, 14 May 2014

The dipeptidyl peptidase-4 inhibitor Saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients

Saxagliptin reverses PACs dysfunction associated with T2D in vitro and improves inducible angiogenesis by circulating cells in vivo. These data add knowledge to the potential pleiotropic cardiovascular effects of DPP-4 inhibition (Cardiovascular Diabetology)

Tuesday, 13 May 2014

Apolipoprotein B and non-HDL cholesterol are more powerful predictors for incident type 2 diabetes than fasting glucose or glycated hemoglobin in subjects with normal glucose tolerance

Atherogenic dyslipidemia was more closely associated with the development of T2D than fasting glucose or glycated hemoglobin in subjects with NGT (Acta Diabetologica)

Effects of insulin resistance on white matter microstructure in middle-aged and older adults

In generally healthy adults, greater IR is associated with alterations in WM tissue integrity. These cross-sectional findings suggest that IR contributes to WM microstructural alterations in middle-aged and older adults (Neurology)

Intensified insulin-based glycaemic control after myocardial infarction

Intensified insulin-based glycaemic control after acute myocardial infarction in patients with diabetes and hyperglycaemia at admission had a long-lasting effect on longevity (The Lancet Diabetes & Endocrinology)

Monday, 12 May 2014

Lilly's Basal Insulin Peglispro Shows Superiority in HbA1c Reduction Compared to Insulin Glargine in Three Phase III Trials in Patients with Type 2 Diabetes

Eli Lilly today announced positive top-line results of three completed Phase III clinical trials in patients with type 2 diabetes for basal insulin peglispro (BIL), which is being studied as a once-daily treatment for both type 1 and type 2 diabetes (Lilly)

Launch of a new alliance for the global assessment of retinopathy

A new project has been launched to assess the awareness, treatment and implications of diabetic retinopathy globally. Results are intended to inform decision-making and policy development around this common and serious complication of diabetes (International Diabetes Federation )

Efficacy of REAL-Time continuous glucose monitoring on glycaemic control and glucose variability in Type 1 diabetic patients treated with either insulin pumps or multiple insulin injection therapy

Appropriate use of REAL-Time CGM improved glyco-metabolic control in T1D patients. The effects of CGM were more evident in patients under MDI treatment, compared to CSII. Glucose variability, in addition to glycaemic control, was improved in compliant diabetic patients. This article is protected by copyright (Diabetes/Metabolism Research and Reviews)

Comparison of Insulin Degludec/Insulin Aspart and Biphasic Insulin Aspart 30 in Uncontrolled, Insulin-Treated Type 2 Diabetes: A Phase 3a, Randomized, Treat-to-Target Trial

IDegAsp BID effectively improves HbA1c and fasting PG levels with fewer hypoglycemia episodes versus BIAsp 30 in patients with uncontrolled type 2 diabetes previously treated with once- or twice-daily pre- or self-mixed insulin (Diabetes Care)

ß-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

This article examines the foundation of ß-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment (Diabetes Care)

Role of epigenetic mechanisms in the development of chronic complications of diabetes

Our review suggests that the treatment of chronic complications should focus on erasing metabolic memory by targeting chromatin modification enzymes and by restoring miRNA levels (Diabetes Research and Clinical Practice)

Ten years of the national genetic diabetes nurse network: a model for the translation of genetic information into clinical care

The GDN project has proved an effective, innovative means of disseminating new genetic information from a centre of excellence and is suggested as a model for the successful and rapid dissemination of genetic information into routine clinical care in other conditions (Royal College of Physicians)

Thursday, 8 May 2014

Variations in the quality and sustainability of long-term glycaemic control with continuous subcutaneous insulin infusion

Improved glycaemic control with continuous subcutaneous insulin infusion was maintained over 5 years by 88% of people with Type 1 diabetes in this study, but there were variations in the long-term efficacy, with some people improving and worsening, others maintaining strict control and a few subcutaneous insulin infusion ‘non-responders’ (Diabetic Medicine)

Wednesday, 7 May 2014

Effect of insulin analogues on risk of severe hypoglycaemia in patients with type 1 diabetes prone to recurrent severe hypoglycaemia (HypoAna trial)

Treatment with insulin detemir and aspart in patients with type 1 diabetes and recurrent severe hypoglycaemia resulted in a clinically significant reduced rate of severe hypoglycaemia compared with human insulin (The Lancet Diabetes & Endocrinology)

Stability and Predictive Utility over 3 Years of Illness Beliefs of Individuals Recently Diagnosed With Type 2 Diabetes Mellitus

Peoples’ beliefs about diabetes are formed quickly after diagnosis, and thereafter seem to be relatively stable over extended follow-up. These early illness beliefs are predictive of later psychological distress, and emphasize the importance of initial context and provision of diabetes care in shaping participants’ future well-being (Diabetic Medicine)

Prediction of gestational diabetes in obese pregnant women from the UK Pregnancies Better Eating and Activity (UPBEAT) pilot trial

A combination of routinely measured clinical factors and adiponectin measured in the early second trimester in obese women may provide a useful approach to the prediction of gestational diabetes (Diabetic Medicine)

Tuesday, 6 May 2014

Effect of Change in Body Weight on Incident Diabetes Mellitus in Patients With Stable Coronary Artery Disease Treated With Atorvastatin

1-year change in body weight is predictive of NODM in patients who underwent statin therapy from the TNT trial. Our study highlights the importance of weight control as a lifestyle measure to prevent statin-related NODM (American Journal of Cardiology)

Monday, 5 May 2014

Effect of Early Multifactorial Therapy Compared With Routine Care on Microvascular Outcomes at 5 Years in People With Screen-Detected Diabetes

Compared with RC, an intervention to promote target-driven, intensive management of patients with type 2 diabetes detected by screening was not associated with significant reductions in the frequency of microvascular events at 5 years (Diabetes Care)

Identification of novel risk genes associated with type 1 diabetes mellitus using a genome-wide gene-based association analysis

The present results suggest the high power of gene-based association analysis in detecting disease-susceptibility genes. Our findings provide more insights into the genetic basis of type 1 diabetes mellitus (Journal of Diabetes Investigation)

Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes

This study suggests that calpain may play a role in vascular endothelial cell ROS production and endothelium-dependent dysfunction in diabetes. Thus, calpain may be an important therapeutic target to overcome diabetes-induced vascular dysfunction (Cardiovascular Diabetology)

Friday, 2 May 2014

Helicobacter pylori infection and diabetes: Is it a myth or fact?

This review probes the possible relationship between H. pylori and diabetes according to epidemiological surveys and discusses putative mechanisms underlying this correlation (World Journal of Gastroenterology)

Youth-Onset Type 2 Diabetes Mellitus: Lessons Learned From the TODAY Study

The significance of the findings from this important trial for the management of youth and young adults with youth-onset type 2 diabetes and its complications is discussed. An aggressive multifaceted approach is needed to prevent or forestall premature microvascular and macrovascular complications in youth-onset type 2 diabetes (Mayo Clinic Proceedings)

Putting the diabetes risk due to statins in perspective: A re-evaluation using the complementary outcome

Statins are associated with only a very small increase in risk of diabetes mellitus. Previous research selected the outcomes with the lower baseline risks and therefore the actual risk associated with statins has been largely over-estimated (Nutrition, Metabolism & Cardiovascular Diseases)

Effect of insulin analogues on risk of severe hypoglycaemia in patients with type 1 diabetes prone to recurrent severe hypoglycaemia (HypoAna trial)

Treatment with insulin detemir and aspart in patients with type 1 diabetes and recurrent severe hypoglycaemia resulted in a clinically significant reduced rate of severe hypoglycaemia compared with human insulin (The Lancet Diabetes & Endocrinology)

Thursday, 1 May 2014

Pantoprazole may improve beta cell function and diabetes mellitus

Pantoprazole administration seems to correlate with increased beta cell function. Pantoprazole administration improves HbA1c, HOMA-B, c-peptide and proinsulin levels. Since beta cell loss plays a significant role in the pathogenesis of type 2 diabetes, PPI-based therapies may be useful in the treatment of diabetes (Journal of Endocrinological Investigation)