Tuesday, 22 July 2014

Defects in ß-Cell Ca2+ Dynamics in Age-Induced Diabetes

Our data suggest that ageing is associated with a progressive decline in ß-cell mitochondrial function that negatively impacts on the fine tuning of Ca2+ dynamics. This is conceptually important since it emphasizes that even relatively modest changes in ß-cell signal-transduction over time lead to compromised insulin release and a diabetic phenotype (Diabetes)


Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): Implications for GLP-1 measurements in clinical studies

The specificity and sensitivity of commercially available kits for analysis of GLP-1 levels varies considerably. This should be taken into account when selecting which assay to use and when comparing data from different studies (Diabetes, Obesity and Metabolism)


Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis

this study provided evidence of the generalized nature of diabetic autonomic neuropathy. Diabetes patients with signs and symptoms of upper GI dysfunction displayed reduced rectal sensitivity to heat and mechanical and electrical stimulation. Also, the heart rate variability was impaired. In a clinical setting, the presence of autonomic dysfunction could be regarded as a diffuse neuropathic complication (Journal of Diabetes Research)

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