Tuesday, 16 December 2014

The impact of diabetes-related complications on healthcare costs: new results from the UKPDS (UKPDS 84)

Diabetic complications are associated with substantial immediate and long-term healthcare costs. Our comprehensive new estimates of these costs, derived from detailed recent UK Prospective Diabetes Study post-trial data, should aid researchers and health policy analyses (Diabetic Medicine)

Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes

The results provides evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, being consistent with the possibility that a low grade enteroviral infection in the pancreatic islets contribute to disease progression in humans (Diabetes)

Low within- and between-day variability in exposure to new insulin glargine 300 U.mL-1

Gla-300 provides predictable, evenly distributed 24-hour coverage due to low fluctuation and high reproducibility in insulin exposure, and appears suitable for effective basal insulin use (Diabetes, Obesity and Metabolism)

Initial Combination Therapy with Metformin/Pioglitazone/Exenatide is More Effective Than Sequential Add-On Therapy in Subjects with New Onset Diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): A Randomized Trial

The results of this exploratory study demonstrate that combination therapy with metformin/pioglitazone/exenatide in newly diagnosed T2DM patients is more effective with less hypoglycemia than sequential add-on therapy with metformin, sulfonylurea, and then basal insulin (Diabetes, Obesity and Metabolism)

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